Table 1.
Demographic characteristics of children with invasive pneumococcal disease (IPD) and pneumococcal colonization pre- and post-PCV10 introduction in Mozambique.
| Characteristics | Pre-PCV10 |
Post-PCV10 |
||||
|---|---|---|---|---|---|---|
| IPD N = 40 n (%) |
Pneumococcal colonization N = 411 n (%) |
P value | IPD N = 30 n (%) |
Pneumococcal colonization N = 507 n (%) |
P value | |
| Sex, male1 | 25 (62.5) | 211 (51.3) | 0.177 | 18 (62.1) | 247 (48.7) | 0.230 |
| Age (months) | ||||||
| Median age (interquartile range) | 12 (7–27.5) | 25.1 (13.1–42.2) | <0.001 | 19.5 (13–30) | 24.5 (13–41.2) | 0.245 |
| Age group 2 | 0.001 | 0.275 | ||||
| 0–11 | 20 (50.0) | 93 (23.1) | 7 (20.7) | 110 (22.0) | ||
| 12–23 | 8 (20.0) | 103 (25.6) | 12 (41.4) | 139 (27.7) | ||
| 24–59 | 12 (30.0) | 207 (51.4) | 11 (37.9) | 252 (50.3) | ||
| Malnutrition 3 | <0.001 | <0.001 | ||||
| None | 23 (59.0) | 343 (85.0) | 15 (48.4) | 453 (89.9) | ||
| Moderate | 6 (15.4) | 44 (10.9) | 8 (22.6) | 42 (8.3) | ||
| Severe | 10 (25.6) | 18 (4.4) | 7 (29.0) | 9 (3.0) | ||
| HIV status 4 | 0.903 | 0.018 | ||||
| Positive | 5 (38.5) | 165 (40.2) | 5 (35.7) | 336 (66.3) | ||
| Negative | 8 (61.5) | 246 (59.9) | 9 (64.3) | 171– (33.7) | ||
| PCV10 Doses 5 | 0.354 | |||||
| 0 Doses | NA | NA | 2 (14.3) | 19 (8.2) | ||
| 1–2 Doses | NA | NA | 3 (21.4) | 32 (13.7) | ||
| 3 Doses | NA | NA | 9 (64.3) | 182 (78.1) | ||
| Clinical manifestation | NA | |||||
| Bacteremic pneumonia | 19 (47.5) | NA | 14 (46.7) | NA | ||
| Bacteremia without pneumonia | 18 (45.0) | NA | 15 (50) | NA | ||
| Meningitis | 3 (7.5) | NA | 1 (3.3) | NA | ||
| Mortality | 6 (15.0) | NA | 1 (3.3) | NA | ||
NA: Not applicable
Post-PCV10: One child with IPD missing sex information.
Pre-PCV10: Eight children with pneumococcal colonization missing age/Post-PCV10: Six children with pneumococcal colonization missing age.
Pre-PCV10: One children with IPD and 6 with pneumococcal colonization missing weight for age Z-score (waz) calculation /Post-PCV: Three children with pneumococcal colonization missing weight for age Z-score (waz) calculation.
Pre-PCV10: Twenty-seven children with IPD missing HIV status/PostPCV10: Sixteen children with IPD missing HIV status.
Post-PCV10: Sixteen children with IPD and 274 children with pneumococcal colonization not age eligible for PCV10.