Table 2.
Invasive disease potential of pneumococcal serotypes among children aged <5 years pre- and post-PCV10 introduction in Mozambique.
| Serotype | Pre-PCV10 |
Post-PCV10 |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Invasive | Carriage | OR | 95% CI | P value | Invasive | Carriage | OR | 95% CI | P value | |
| 1 | 2 | 1 | 22.3 | 2.0–251.2 | 0.041 | 3 | 0 | NA | NA | NA |
| 4 | 2 | 6 | 3.7 | 0.7–18.8 | 0.291 | 0 | 4 | NA | NA | NA |
| 5 | 2 | 0 | NA | NA | NA | 1 | 1 | 18.6 | 1.1–304.6 | 0.205 |
| 6B | 6 | 23 | 3.1 | 1.2–8.1 | 0.017 | 2 | 25 | 1.5 | 0.3–6.5 | 0.845 |
| 9V | 2 | 9 | 2.4 | 0.5–11.6 | 0.487 | 0 | 11 | NA | NA | NA |
| 14 | 5 | 17 | 3.4 | 1.2–9.8 | 0.016 | 0 | 14 | NA | NA | NA |
| 18C | 1 | 5 | 2.1 | 0.2–18.9 | 0.839 | 0 | 1 | NA | NA | NA |
| 19F | 3 | 59 | 0.5 | 0.1–1.7 | 0.375 | 1 | 37 | 0.5 | 0.1–3.5 | 0.779 |
| 23F | 4 | 52 | 0.8 | 0.3–2.3 | 0.911 | 1 | 43 | 0.4 | 0.1–3.0 | 0.615 |
| 3 | 1 | 7 | 1.5 | 0.2–12.7 | >0.910 | 0 | 13 | NA | NA | NA |
| 6A | 7 | 43 | 1.9 | 0.8–4.5 | 0.152 | 11 | 47 | 6.1 | 2.7–13.5 | 0.001 |
| 19A | 0 | 17 | NA | NA | NA | 2 | 38 | 0.9 | 0.2–4.1 | >0.910 |
| 7C | 1 | 8 | 1.3 | 0.2–10.9 | >0.910 | 2 | 29 | 1.3 | 0.3–5.5 | 0.992 |
| 8 | 1 | 1 | 10.9 | 0.7–176.8 | 0.330 | 0 | 3 | NA | NA | NA |
| 9N | 0 | 6 | NA | NA | NA | 1 | 6 | 3.1 | 0.4–26.3 | 0.633 |
| 12F | 0 | 3 | NA | NA | NA | 1 | 0 | NA | NA | NA |
| 13 | 0 | 25 | NA | NA | NA | 3 | 33 | 1.7 | 0.5–5.9 | 0.585 |
| 15B | 1 | 18 | 0.6 | 0.1–4.4 | 0.910 | 0 | 21 | NA | NA | NA |
| 18A | 1 | 2 | 5.4 | 0.5–61 | 0.475 | 0 | 1 | NA | NA | NA |
| 35B | 1 | 14 | 0.8 | 0.1–5.9 | >0.910 | 0 | 14 | NA | NA | NA |
| NT | 0 | 23 | NA | NA | NA | 2 | 43 | 0.8 | 0.2–3.6 | >0.910 |
| Other 1 | 0 | 85 | NA | NA | NA | 0 | 156 | NA | NA | NA |
| Total | 40 | 424 | 30 | 540 | ||||||
95% CI: 95% confidence interval.
OR: Odds ratio.
NA: Not applicable.
1
Pre-PCV10 Include serotypes: 7B, 9A, 9L, 10A, 10B, 11A, 15A, 15C, 16F, 17F, 19B, 20, 21, 22A, 23A, 23B, 24F, 28F, 31, 33D, 34, and 35A. Post-PCV10 include serotypes: 6C, 9L, 10A, 11A, 15A, 15C, 16F, 17F, 19B, 20, 21, 23A, 23B, 24F, 28F, 29, 31, 33C, 34, 35F, 38, and 46.