TABLE 3.
Top 10 genes correlated with dd-cfDNA (cp/mL) from random subsamplings of 37 biopsies within AMR (N = 171)
| Genes by all AMR biopsies | Subsampling | Genes within subsampling | Interpretation |
|---|---|---|---|
|
CCL3
WARS CCL3L1 ROBO4 CCL4 ICAM2 STX11 IDO1 LYPD5 CCL4 |
1 | ROBO4, SH2D1B, LTF, IDO1, CCL4, PLA1A, LYPD5, EGR1, ZBED2, WARS | Genes related to AMR (eg, WARS, ROBO4) and IFNG effects (eg, CXCL11) are represented across all subsamplings |
| 2 | CCL4, IDO1, PLA1A, WARS, S1PR5, PRF1, FGFBP2, GNLY, GBP4, LYPD5 | ||
| 3 | LYPD5, WARS, ROBO4, GBP4, LTF, CXCL11, CCL4, IDO1, PLA1A, BATF | ||
| 4 | WARS, CXCL11, CXCL10, PRF1, ROBO4, LYPD5, CXCL9, IDO1, CCL4, GBP4 | ||
| 5 | LYPD5, PLA1A, ROBO4, WARS, KLRF1, IDO1, CXCL11, SH2D1B, CCL4, CXCL10 | ||
| 6 | GNLY, SERPINA3, WARS, CXCL10, ROBO4, CXCL9, PRF1, CCL4, GBP4, LYPD5 | ||
| 7 | EGR1, GNLY, S1PR5, FGFBP2, ROBO4, LTF, PRF1, PTX3, KLRF1, TIGIT | ||
| 8 | WARS, SH2D1B, LYPD5, GBP4, CCL4, CXCL11, GNLY, LTF, CXCL9, ROBO4 | ||
| 9 | CCL4, IDO1, GNLY, LYPD5, GBP4, CXCL10, IFNG, CXCL11, CXCL9, AKAP12 | ||
| 10 | GNLY, CXCL11, WARS, IDO1, KLRF1, CXCL10, PRF1, GBP4, CCL4, ROBO4 |
AMR, antibody-mediated rejection; dd-cfDNA, donor-derived cell-free DNA; IFNG, interferon gamma.