TABLE 4.

Summary of molecular score SCCs with dd-cfDNA (cp/mL) within subgroup

Category	Molecular score	AMR N = 171	TCMR N = 37	cAKI N = 50	Normal N = 312	NRNI N = 134	All N = 604
All rejection–related	Peritubular capillaritis classifier (ptc > 0Prob)	0.44*	0.57*	0.31	0.25*	0.29*	0.60*
	Rejection classifier (RejProb)	0.40*	0.56*	0.30	0.25*	0.32*	0.58*
	Interferon gamma-inducible (GRIT3)	0.28*	0.32	0.30	0.23*	0.29*	0.49*
AMR-related	AMR classifier (AMRProb)	0.48*	0.30	0.22	0.23*	0.31*	0.56*
	Glomerulitis classifier (g > 0Prob)	0.47*	0.39	0.26	0.18*	0.21	0.56*
TCMR-related	TCMR classifier (TCMRProb)	0.03	0.26	−0.04	0.13	0.10	0.25*
	t-score classifier (t > 1Prob)	0.04	0.33	0.05	0.14	0.12	0.27*
Recent injury–related	Injury repair–associated transcripts (IRRAT30)	−0.04	−0.11	0.41*	0.16*	0.10	0.26*
Cell cycle–related	Cell cycle KEGG pathway (cell cycle KEGG)	0.10	0.02	0.40*	0.22*	0.20	0.32*
Apoptosis-related	Apoptosis KEGG pathway (apoptosis KEGG)	0.17	−0.10	0.29	0.19*	0.25*	0.37*
No injury-related	Injury archetype no injury score	0.02	0.26	−0.26	−0.21*	−0.25*	−0.25*
No rejection-related	Rejection archetype no rejection score	−0.26*	−0.41	−0.30	−0.27*	−0.27*	−0.57*

*P value < 0.01. Gray shading highlights absolute SCCs ≥ 0.4.

AMR, antibody–mediated rejection; cAKI, clinical acute kidney injury; dd-cfDNA, donor-derived cell-free DNA; KEGG, Kyoto Encyclopedia of Genes and Genomes; SCC, Spearman correlation coefficients; TCMR, T cell–mediated rejection.