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. 2024 Mar 11;55(4):1032–1040. doi: 10.1161/STROKEAHA.123.045857

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© 2024 The Authors.

Stroke is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 1. — Diffusion tensor image (DTI) analysis along the perivascular space (DTI-ALPS) workflow. dtifit: command provided by FSL used to calculate fractional anisotropy (FA) and V1 images from DTI. flirt: command provided by FSL used for registering individual images to a standardized space. V1 is the first eigenvector image derived from DTI, indicating the primary direction of fiber pathways in specific brain regions. Blue color denotes superior to inferior fibers, green indicates anterior to posterior fibers, and red signifies left to right fibers. Dxx indicates diffusivity along the perivascular space, signifying left to right directional diffusion; Dyy, diffusivity along projection fibers, indicating superior to inferior directional diffusion; Dzz, diffusivity along association fibers, depicting anterior to posterior directional diffusion; FSL, Oxford Centre for Functional Magnetic Resonance Imaging of the Brain Software Library; and ROI, region of interest.