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. 2024 Mar 25;10(2):00891-2023. doi: 10.1183/23120541.00891-2023

TABLE 1.

Current and future therapeutic options in chronic cough

Target receptor Type of receptor Drug name Mechanism of action
P2X3 Peripheral receptor Gefapixant#, eliapixant, sivopixant, camlipixant Antagonist
NaV1.7 Peripheral receptor NTX-1175 Blockers
TRPM8 Peripheral receptor AX-8 Antagonist
NK-1 Central receptor Aprepitant, orvepitant Antagonist

P2X3: purinoceptor 3; TRPM8: transient receptor potential cation channel subfamily M (melastatin) member 8; NK-1: neurokinin-1 receptor. #: phase 3 trial completed.