TABLE 1.

Clinical and histopathological profiles of SIV-immunosuppressed monkeys with SV40 infection

Monkey	Agea	Survivalb	Clinical signs	Cause of death	Histopathology
6593	15	568	Weight loss, anorexia	SV40 encephalitis	SV40 lesions in brain (+++) and spinal column (+); lymphoma in kidney
H328	7	1,016	Head tilt, no nystagmus	SV40 encephalitis	SV40 PML-type lesions in brain and brain stem (+++); endocardiosis; M. avium lesions in lung, liver, and lymph node (+++); Epstein-Barr virus-associated oral leukoplakia-type lesions in esophagus
H491	5	911	Weakness, ataxia, diarrhea, dehydration	Enterocolitis	SV40 lesions in brain stem (++) and spinal cord (+); M. avium in liver, spleen, lymph node, small intestine, and colon
H388	6	317	Diarrhea, weight loss, dehydration	Enteritis	SV40-associated focal inflammation in brain (+); M. avium in lung, liver, spleen, lymph node, small intestine, and colon
H822	3	577	Dilated nonresponsive pupils, diarrhea, wasting	Diarrhea	SIV syncytia in mesenteric lymph nodes and small and large intestines; SV40 lesions in brain stem and superficial cortex; moderate glomerulosclerosis; Candida sp. in tongue
I508	2	368	Diarrhea, wasting	Cryptosporidiosis	SV40 lesions in brain (++); cryptosporidia in lung, trachea, gall bladder, small intestine, and stomach
K661	3	555	Weakness, anorexia, diarrhea	SV40 infection	SV40 lesions in brain (+), lung (++), thymus (++), small intestine (++), and kidney (+++); M. avium lesions in lymph node, liver, and spleen; Candida sp. in uterus and tongue; adenovirus lesions in colonic mucous membranes
T302	0.8	275	Anorexia, ataxia, blindness	SV40 infection	SV40 lesions in optic nerve (+++), brain (++), lung (++), and kidney (++); adenoviral pancreatitis; Candida sp. in tongue

^aAge in years at death. 

^bSurvival in days postinoculation with SIV.