Table 2.
Pharmacokinetic parameters of chlorogenic acid (n = 6).
| PK parameters | Chlorogenic acid | ||
|---|---|---|---|
|
| |||
| GHI-L | GHI-M | GHI-H | |
| t1/2α (h) | 0.034 ± 0.009 | 0.031 ± 0.003 | 0.018 ± 0.003 |
| t1/2β (h) | 0.919 ± 0.079 | 0.829 ± 0.121 | 0.52 ± 0.052 |
| V1 (L/kg) | 0.672 ± 0.201 | 0.496 ± 0.08 | 0.389 ± 0.059 |
| V2 (L/kg) | 2.304 ± 0.146 | 1.49 ± 0.142 | 1.273 ± 0.103 |
| CL1 (L/h/kg) | 2.669 ± 0.169 | 1.939 ± 0.146 | 2.554 ± 0.092 |
| CL2 (L/h/kg) | 8.99 ± 0.907 | 7.19 ± 0.505 | 10.403 ± 0.914 |
| AUC(0-t) (μg/L*h) | 99.028 ± 52.832 | 268.98 ± 142.21 | 408.232 ± 212.364 |
| AUC(0-∞) (μg/L*h) | 102.146 ± 53.386 | 277.105 ± 142.174 | 421.197 ± 211.864 |
| K10 (1/h) | 4.274 ± 1.912 | 3.987 ± 0.663 | 6.701 ± 1.078 |
| K12 (1/h) | 14.327 ± 4.021 | 14.709 ± 1.766 | 27.459 ± 6.003 |
| K21 (1/h) | 3.902 ± 0.294 | 4.84 ± 0.29 | 8.203 ± 0.823 |
| Q (L/h/kg) | 8.991 ± 0.908 | 7.190 ± 0.504 | 10.398 ± 0.912 |