Table 3.
Pharmacokinetic parameters of hydroxysafflor yellow A (n = 6).
| PK parameters | Hydroxysafflor yellow A | ||
|---|---|---|---|
|
| |||
| GHI-L | GHI-M | GHI-H | |
| t1/2α (h) | 0.017 ± 0.012 | 0.01 ± 0.003 | 0.024 ± 0.006 |
| t1/2β (h) | 0.732 ± 0.1 | 1.386 ± 0.079 | 0.972 ± 0.109 |
| V1 (L/kg) | 0.218 ± 0.194 | 0.126 ± 0.071 | 0.498 ± 0.088 |
| V2 (L/kg) | 0.838 ± 0.35 | 1.351 ± 0.099 | 1.001 ± 0.108 |
| CL1 (L/h/kg) | 1.22 ± 0.369 | 0.831 ± 0.078 | 1.13 ± 0.031 |
| CL2 (L/h/kg) | 4.617 ± 2.905 | 6.72 ± 2.765 | 9.462 ± 1.509 |
| AUC(0-t) (μg/L*h) | 39.625 ± 19.79 | 112.634 ± 61.077 | 186.919 ± 99.005 |
| AUC(0-∞) (μg/L*h) | 40.679 ± 19.68 | 115.716 ± 61.354 | 190.363 ± 98.813 |
| K10 (1/h) | 24.474 ± 30.867 | 9.794 ± 7.36 | 2.321 ± 0.37 |
| K12 (1/h) | 41.769 ± 28.827 | 61.177 ± 16.942 | 19.794 ± 6.115 |
| K21 (1/h) | 4.939 ± 2.249 | 4.88 ± 1.799 | 9.604 ± 2.209 |
| Q (L/h/kg) | 4.621 ± 2.906 | 6.711 ± 2.762 | 9.465 ± 1.508 |