Table 4.
Pharmacokinetic parameters of hyperoside (n = 6).
| PK parameters | Hyperoside | ||
|---|---|---|---|
|
| |||
| GHI-L | GHI-M | GHI-H | |
| t1/2α (h) | 0.023 ± 0.005 | 0.023 ± 0.005 | 0.015 ± 0.004 |
| t1/2β (h) | 0.669 ± 0.077 | 0.312 ± 0.022 | 0.313 ± 0.062 |
| V1 (L/kg) | 0.493 ± 0.117 | 0.34 ± 0.1 | 0.309 ± 0.126 |
| V2 (L/kg) | 2.979 ± 0.292 | 0.935 ± 0.119 | 1.207 ± 0.352 |
| CL1 (L/h/kg) | 5.336 ± 0.493 | 4.595 ± 0.202 | 4.915 ± 0.718 |
| CL2 (L/h/kg) | 8.691 ± 0.628 | 4.573 ± 0.67 | 7.256 ± 2.273 |
| AUC(0-t) (μg/L*h) | 7.719 ± 4.061 | 17.724 ± 9.103 | 32.246 ± 15.108 |
| AUC(0-∞) (μg/L*h) | 8.252 ± 4.022 | 19.295 ± 9.27 | 34.504 ± 14.937 |
| K10 (1/h) | 11.259 ± 2.48 | 14.742 ± 5.174 | 21.205 ± 16.45 |
| K12 (1/h) | 18.242 ± 3.358 | 14.086 ± 2.688 | 26.235 ± 8.526 |
| K21 (1/h) | 2.929 ± 0.214 | 4.889 ± 0.407 | 6.031 ± 0.862 |
| Q (L/h/kg) | 8.690 ± 0.628 | 4.572 ± 0.672 | 7.260 ± 2.271 |