Table 5.
Pharmacokinetic parameters of kaempferol-3-O-glucoside (n = 6).
| PK parameters | Kaempferol-3-O-glucoside | ||
|---|---|---|---|
|
| |||
| GHI-L | GHI-M | GHI-H | |
| t1/2α (h) | 0.026 ± 0.005 | 0.045 ± 0.024 | 0.022 ± 0.002 |
| t1/2β (h) | 0.674 ± 0.094 | 0.691 ± 0.361 | 0.385 ± 0.053 |
| V1 (L/kg) | 0.54 ± 0.101 | 0.59 ± 0.22 | 0.475 ± 0.044 |
| V2 (L/kg) | 2.822 ± 0.3 | 1.87 ± 0.735 | 1.419 ± 0.173 |
| CL1 (L/h/kg) | 5.255 ± 0.593 | 4.123 ± 0.508 | 4.4558 ± 0.452 |
| CL2 (L/h/kg) | 7.999 ± 1.661 | 4.766 ± 1.069 | 8.474 ± 0.613 |
| AUC(0-t) (μg/L*h) | 23.576 ± 12.633 | 31.49 ± 12.303 | 116.314 ± 56.651 |
| AUC(0-∞) (μg/L*h) | 25.109 ± 12.653 | 35.448 ± 11.949 | 122.652 ± 56.297 |
| K10 (1/h) | 10.09 ± 2.541 | 8.042 ± 3.472 | 9.636 ± 0.934 |
| K12 (1/h) | 15.148 ± 3.65 | 9.709 ± 5.342 | 17.927 ± 1.512 |
| K21 (1/h) | 2.832 ± 0.492 | 3.087 ± 1.742 | 6.02 ± 0.636 |
| Q (L/h/kg) | 7.998 ± 1.660 | 4.764 ± 1.067 | 8.473 ± 0.613 |