Table 6.
Pharmacokinetic parameters of kaempferol-3-O-rutinoside (n = 6).
| PK parameters | Kaempferol-3-O-rutinoside | ||
|---|---|---|---|
|
| |||
| GHI-L | GHI-M | GHI-H | |
| t1/2α (h) | 0.024 ± 0.008 | 0.045 ± 0.025 | 0.022 ± 0.004 |
| t1/2β (h) | 0.563 ± 0.116 | 0.621 ± 0.352 | 0.348 ± 0.047 |
| V1 (L/kg) | 0.546 ± 0.192 | 0.603 ± 0.211 | 0.49 ± 0.094 |
| V2 (L/kg) | 2.437 ± 0.538 | 1.669 ± 0.725 | 1.244 ± 0.167 |
| CL1 (L/h/kg) | 5.158 ± 0.266 | 4.134 ± 0.338 | 4.481 ± 0.265 |
| CL2 (L/h/kg) | 9.313 ± 2.573 | 4.919 ± 1.189 | 8.486 ± 0.614 |
| AUC(0-t) (μg/L*h) | 163.614 ± 83.456 | 211.446 ± 86.297 | 778.474 ± 381.478 |
| AUC(0-∞) (μg/L*h) | 172.917 ± 84.754 | 236.738 ± 84.799 | 819.682 ± 380.899 |
| K10 (1/h) | 10.77 ± 4.722 | 7.644 ± 2.745 | 9.381 ± 1.601 |
| K12 (1/h) | 19.134 ± 9.171 | 9.432 ± 4.449 | 17.849 ± 3.532 |
| K21 (1/h) | 3.903 ± 1.019 | 3.686 ± 2.064 | 6.923 ± 0.999 |
| Q (L/h/kg) | 9.311 ± 2.570 | 4.919 ± 1.190 | 8.485 ± 0.615 |