Table 7.
Pharmacokinetic parameters of N-acetyl-L-glutamine (n = 6).
| PK parameters | N-acetyl-L-glutamine | ||
|---|---|---|---|
|
| |||
| GHI-L | GHI-M | GHI-H | |
| t1/2α (h) | 0.014 ± 0.003 | 0.005 ± 0.001 | 0.018 ± 0.011 |
| t1/2β (h) | 0.814 ± 0.078 | 0.462 ± 0.023 | 0.709 ± 0.083 |
| V1 (L/kg) | 0.223 ± 0.057 | 0.024 ± 0.008 | 0.339 ± 0.204 |
| V2 (L/kg) | 1.381 ± 0.093 | 0.445 ± 0.069 | 1.144 ± 0.167 |
| CL1 (L/h/kg) | 1.577 ± 0.116 | 1.133 ± 0.122 | 1.633 ± 0.135 |
| CL2 (L/h/kg) | 8.185 ± 1.181 | 1.776 ± 0.548 | 8.632 ± 3.038 |
| AUC(0-t) (μg/L*h) | 538.219 ± 290.308 | 1012.749 ± 472.353 | 1048.88 ± 551.764 |
| AUC(0-∞) (μg/L*h) | 553.382 ± 290.017 | 1060.065 ± 473.211 | 1079.308 ± 551.248 |
| K10 (1/h) | 7.691 ± 3.042 | 50.018 ± 3.042 | 9.543 ± 11.62 |
| K12 (1/h) | 38.711 ± 10.279 | 73.95 ± 2.602 | 37.368 ± 24.261 |
| K21 (1/h) | 5.932 ± 0.785 | 3.913 ± 0.6 | 7.43 ± 2.404 |
| Q (L/h/kg) | 8.185 ± 1.181 | 1.771 ± 0.553 | 8.631 ± 3.051 |