Table 8.
Pharmacokinetic parameters of p-coumaric acid (n = 6).
| PK parameters | p-Coumaric acid | ||
|---|---|---|---|
|
| |||
| GHI-L | GHI-M | GHI-H | |
| t1/2α (h) | 0.03 ± 0.009 | 0.037 ± 0.025 | 0.034 ± 0.01 |
| t1/2β (h) | 0.487 ± 0.059 | 0.392 ± 0.084 | 0.321 ± 0.049 |
| V1 (L/kg) | 0.462 ± 0.17 | 0.677 ± 0.122 | 0.723 ± 0.095 |
| V2 (L/kg) | 1.272 ± 0.124 | 0.7 ± 0.142 | 0.669 ± 0.07 |
| CL1 (L/h/kg) | 3.317 ± 0.369 | 2.808 ± 0.134 | 3.469 ± 0.187 |
| CL2 (L/h/kg) | 5.909 ± 1.304 | 6.918 ± 2.46 | 6.658 ± 2.185 |
| AUC(0-t) (μg/L*h) | 380.718 ± 210.96 | 942.029 ± 503.001 | 1526.046 ± 777.772 |
| AUC(0-∞) (μg/L*h) | 400.705 ± 216.195 | 969.468 ± 504.903 | 1579.385 ± 775.148 |
| K10 (1/h) | 8.039 ± 2.934 | 4.277 ± 0.897 | 4.878 ± 0.808 |
| K12 (1/h) | 14.117 ± 4.736 | 11.023 ± 5.384 | 9.545 ± 4.156 |
| K21 (1/h) | 4.662 ± 1.024 | 10.302 ± 3.876 | 10.071 ± 3.659 |
| Q (L/h/kg) | 5.909 ± 1.300 | 6.919 ± 2.461 | 6.656 ± 2.183 |