Table 9.
Pharmacokinetic parameters of rutin (n = 6).
| PK parameters | Rutin | ||
|---|---|---|---|
|
| |||
| GHI-L | GHI-M | GHI-H | |
| t1/2α (h) | 0.024 ± 0.002 | 0.035 ± 0.01 | 0.012 ± 0.006 |
| t1/2β (h) | 0.541 ± 0.055 | 0.492 ± 0.082 | 0.348 ± 0.047 |
| V1 (L/kg) | 0.379 ± 0.071 | 0.466 ± 0.88 | 0.239 ± 0.209 |
| V2 (L/kg) | 1.671 ± 0.12 | 1.075 ± 0.133 | 0.855 ± 0.277 |
| CL1 (L/h/kg) | 3.795 ± 0.496 | 2.872 ± 0.264 | 2.813 ± 0.459 |
| CL2 (L/h/kg) | 6.267 ± 0.809 | 5.018 ± 0.665 | 6.712 ± 3.688 |
| AUC(0-t) (μg/L*h) | 34.647 ± 19.017 | 124.334 ± 65.117 | 209.185 ± 106.205 |
| AUC(0-∞) (μg/L*h) | 36.886 ± 19.221 | 129.725 ± 65.166 | 217.984 ± 105.554 |
| K10 (1/h) | 10.125 ± 0.978 | 6.448 ± 1.858 | 25.55 ± 19.846 |
| K12 (1/h) | 16.754 ± 1.998 | 11.318 ± 3.536 | 42.24 ± 19.866 |
| K21 (1/h) | 3.748 ± 0.381 | 4.751 ± 1.024 | 7.333 ± 1.971 |
| Q (L/h/kg) | 6.267 ± 0.813 | 5.018 ± 0.665 | 6.706 ± 3.691 |