Suppl. Table 10.
The main PK parameters of isomucronulatol 7-O-glucoside in rat plasma after oral administration of different formulations. (Mean ± SD, n = 6)
| Parameter | Group | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
|
||||||||||
| formulation 1 | formulation 2 | formulation 3 | formulation 4 | formulation 5 | formulation 6 | formulation 7 | formulation 8 | formulation 9 | ||
| T1/2(h) | 12.21 ± 1.54 | 10.79 ± 2.52 | 11.36 ± 3.54 | 8.59 ± 2.12 | 16.83 ± 2.34 | 18.36 ± 3.87 | 10.41 ± 1.59 | 14.3 ± 0.98 | 9.38 ± 1.07 | |
| Tmax(h) | 0.84 ± 0.12 | 0.79 ± 0.24 | 0.65 ± 0.16 | 0.71 ± 0.09 | 0.69 ± 0.56 | 0.59 ± 0.19 | 0.57 ± 0.11 | 1.06 ± 0.41 | 0.58 ± 0.08 | |
| Cmax(μg/L) | 266.61 ± 12.25 | 257.25 ± 15.97 | 348.01 ± 42.12 | 751.24 ± 24.13 | 897.56 ± 56.89 | 843.52 ± 123.87 | 1331.45 ± 251.22 | 1164.47 ± 245.23 | 1206.5 ± 274.25 | |
| AUC(0-t) (μg/L*h) | 499.42 ± 96.15 | 434.36 ± 145.65 | 371.28 ± 65.42 | 1661.32 ± 351.25 | 1103.95 ± 128.98 | 1463.29 ± 426.56 | 1385.05 ± 200.21 | 1611.12 ± 298.64 | 1502.11 ± 318.29 | |
| MRT(0-t) (h) | 5.56 ± 0.45 | 6.17 ± 25 | 6.41 ± 0.64 | 3.81 ± 0.12 | 1.83 ± 0.46 | 3.79 ± 0.31 | 5.51 ± 1.02 | 5.16 ± 0.23 | 4.79 ± 0.64 | |