Suppl. Table 11.
The main PK parameters of 9,10-dimethoxyptercarpan-3-O-β-D-glucoside in rat plasma after oral administration of different formulations. (Mean ± SD, n = 6)
| Parameter | Group | ||||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| formulation 1 | formulation 2 | formulation 3 | formulation 4 | formulation 5 | formulation 6 | formulation 7 | formulation 8 | formulation 9 | |
| T1/2(h) | 6.98 ± 0.74 | 12.63 ± 0.69 | 14.55 ± 0.92 | 6.87 ± 0.58 | 9.31 ± 0.67 | 6.77 ± 0.77 | 3.53 ± 0.35 | 4.73 ± 0.44 | 12.25 ± 1.05 |
| Tmax(h) | 0.79 ± 0.11 | 0.58 ± 0.05 | 0.55 ± 0.04 | 0.51 ± 0.06 | 0.78 ± 0.07 | 0.64 ± 0.06 | 2.01 ± 0.14 | 1.11 ± 0.25 | 0.64 ± 0.07 |
| Cmax(μg/L) | 148.56 ± 22.01 | 139.49 ± 19.99 | 612 ± 44.32 | 268.1 ± 41.32 | 182.2 ± 20.01 | 348.65 ± 45.12 | 104.5 ± 19.16 | 234.12 ± 41.02 | 564.7 ± 66.32 |
| AUC(0-t) (μg/L*h) | 377.54 ± 31.10 | 608.78 ± 77.64 | 3073.78 ± 226.45 | 2072.65 ± 251.64 | 416.19 ± 36.49 | 123.05 ± 24.11 | 567.56 ± 69.45 | 546.74 ± 62.15 | 1750.18 ± 196.64 |
| MRT(0-t) (h) | 4.54 ± 0.55 | 7.93 ± 0.46 | 9.29 ± 0.37 | 8.49 ± 0.49 | 4.48 ± 0.61 | 6.99 ± 1.05 | 5.65 ± 0.96 | 3.51 ± 0.43 | 7.42 ± 0.85 |