Suppl. Table 14.
The main PK parameters of hydroxysafflor yellow A in rat plasma after oral administration of different formulations. (Mean ± SD, n = 6)
| Parameter | Group | ||||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| formulation 1 | formulation 2 | formulation 3 | formulation 4 | formulation 5 | formulation 6 | formulation 7 | formulation 8 | formulation 9 | |
| 1/2(h) | 10.91 ± 1.06 | 15.52 ± 1.17 | 7.97 ± 0.96 | 17.33 ± 0.48 | 11.01 ± 1.06 | 9.51 ± 1.27 | 18.95 ± 1.96 | 11.84 ± 0.96 | 9.51 ± 0.88 |
| Tmax(h) | 1.04 ± 0.23 | 0.79 ± 0.19 | 0.35 ± 0.09 | 1.11 ± 0.06 | 0.78 ± 0.08 | 2.11 ± 0.25 | 0.58 ± 0.04 | 0.77 ± 0.05 | 0.66 ± 0.04 |
| Cmax(μg/L) | 8040.12 ± 552.06 | 8302.05 ± 414.14 | 4435.22 ± 298.69 | 2296.31 ± 252.45 | 20590.01 ± 1548.94 | 4385.04 ± 354.21 | 27770.06 ± 1974.44 | 11970.25 ± 1064.22 | 15650.2 ± 1232.08 |
| AUC(0-t) (μg/L*h) | 22514.55 ± 1421.49 | 9252.02 ± 212.21 | 16325.79 ± 1456.28 | 7390.05 ± 365.54 | 36045.26 ± 1946.61 | 21639.42 ± 1783.26 | 40825.12 ± 2001.4 | 36872.11 ± 1889.51 | 36370.11 ± 1639.77 |
| MRT(0-t) (h) | 7.54 ± 1.23 | 6.47 ± 0.25 | 8.11 ± 0.66 | 8.56 ± 0.76 | 3.42 ± 0.34 | 5.85 ± 0.46 | 5.89 ± 0.64 | 6.11 ± 0.74 | 4.71 ± 0.69 |