Suppl. Table 15.
The main PK parameters of anhydrosafflor yellow B in rat plasma after oral administration of different formulations. (Mean ± SD, n = 6)
| Parameter | Group | ||||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| formulation 1 | formulation 2 | formulation 3 | formulation 4 | formulation 5 | formulation 6 | formulation 7 | formulation 8 | formulation 9 | |
| T1/2(h) | 17.84 ± 1.22 | 10.65 ± 0.95 | 8.86 ± 0.44 | 11.04 ± 1.06 | 20.65 ± 2.58 | 10.17 ± 1.05 | 11.73 ± 1.21 | 5.05 ± 0.25 | 11.21 ± 0.64 |
| Tmax(h) | 1.21 ± 0.22 | 0.79 ± 0.11 | 0.58 ± 0.05 | 0.48 ± 0.02 | 0.39 ± 0.04 | 0.64 ± 0.07 | 0.71 ± 0.04 | 0.76 ± 0.09 | 1.05 ± 0.03 |
| Cmax(μg/L) | 4232.45 ± 264.54 | 2913.04 ± 623.21 | 7272.05 ± 456.21 | 2929.05 ± 194.26 | 4053.02 ± 189.52 | 11990 ± 678.88 | 16180.25 ± 1125.54 | 4208.05 ± 214.12 | 7543.14 ± 335.77 |
| AUC(0-t) (μg/L*h) | 13037.64 ± 1101.56 | 8535.66 ± 636.58 | 32295.34 ± 1985.89 | 9439.2 ± 457.55 | 8422.52 ± 458.52 | 19378.86 ± 1487.64 | 23141.43 ± 864.19 | 8322.75 ± 565.22 | 10533.37 ± 697.44 |
| MRT(0-t) (h) 7.08 ± 0.64 | 7.07 ± 0.78 | 5.25 ± 0.22 | 7.19 ± 0.56 | 4.86 ± 0.47 | 7.77 ± 0.98 | 5.46 ± 0.15 | 5.04 ± 0.54 | 4.01 ± 1.59 | |