Suppl. Table 16.
The main PK parameters of carthamin in rat plasma after oral administration of different formulations. (Mean ± SD, n = 6)
| Parameter | Group | ||||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| formulation 1 | formulation 2 | formulation 3 | formulation 4 | formulation 5 | formulation 6 | formulation 7 | formulation 8 | formulation 9 | |
| T1/2(h) | 5.96 ± 0.78 | 7.03 ± 1.05 | 5.78 ± 0.96 | 6.4 ± 0.46 | 4.96 ± 0.62 | 6.39 ± 0.74 | 6.28 ± 0.74 | 6.14 ± 0.66 | 6.19 ± 0.61 |
| Tmax(h) | 1.12 ± 0.11 | 1.21 ± 0.13 | 1.07 ± 0.48 | 0.79 ± 0.22 | 1.11 ± 0.05 | 0.58 ± 0.06 | 1.07 ± 0.09 | 0.79 ± 0.08 | 1.07 ± 0.07 |
| Cmax(μg/L) | 1677.45 ± 264.16 | 465.15 ± 65.21 | 751.15 ± 45.56 | 9518 ± 355.05 | 732.1 ± 74.36 | 3285 ± 325.14 | 452.12 ± 36.18 | 501.12 ± 41.08 | 298.4 ± 45.25 |
| AUC(0-t) (μg/L*h) | 3145.31 ± 226.64 | 2692.89 ± 198.54 | 3612.89 ± 332.45 | 20100.7 ± 987.98 | 2391.29 ± 364.21 | 6298.82 ± 478.77 | 3996.49 ± 269.48 | 2510.01 ± 199.88 | 2761.95 ± 206.94 |
| MRT(0-t) (h) | 3.75 ± 0.64 | 6.76 ± 0.98 | 5.11 ± 1.03 | 4.08 ± 0.66 | 5.06 ± 0.78 | 4.91 ± 0.92 | 6.01 ± 0.86 | 6.55 ± 0.69 | 6.21 ± 1.04 |