Suppl. Table 6.
The main PK parameters of calycosin in rat plasma after oral administration of different formulations. (Mean ± SD, n = 6)
| Parameter | Group | ||||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| formulation 1 | formulation 2 | formulation 3 | formulation 4 | formulation 5 | formulation 6 | formulation 7 | formulation 8 | formulation 9 | |
| T1/2(h) | 14.41 ± 2.48 | 10.36 ± 1.66 | 12.17 ± 1.06 | 15.91 ± 1.77 | 10.19 ± 2.01 | 12.06 ± 1.69 | 10.84 ± 2.64 | 8.57 ± 1.01 | 6.71 ± 0.87 |
| Tmax(h) | 0.14 ± 0.04 | 0.26 ± 0.07 | 0.25 ± 0.06 | 0.17 ± 0.08 | 0.15 ± 0.05 | 0.16 ± 0.06 | 0.11 ± 0.03 | 0.12 ± 0.01 | 0.26 ± 0.08 |
| Cmax(μg/L) | 203.21 ± 63.13 | 115.03 ± 24.11 | 133.91 ± 21.99 | 502.32 ± 45.64 | 839.5 ± 110.21 | 847.32 ± 97.33 | 603.74 ± 78.91 | 856.32 ± 54.52 | 1434 ± 155.12 |
| AUC(0-t) (μg/L*h) | 680.22 ± 55.56 | 347.43 ± 44.64 | 466.34 ± 57.51 | 724.84 ± 65.41 | 691.47 ± 44.10 | 716.43 ± 115.12 | 522.11 ± 77.44 | 876.96 ± 69.41 | 1187.09 ± 221.44 |
| MRT(0-t) (h) | 6.87 ± 0.64 | 6.45 ± 0.78 | 7.22 ± 1.02 | 7.21 ± 0.99 | 4.99 ± 0.57 | 4.89 ± 1.06 | 5.73 ± 0.79 | 4.38 ± 0.76 | 3.38 ± 0.35 |