Suppl. Table 7.
The main PK parameters of calycosin-7-O-β-D-glucoside in rat plasma after oral administration of different formulations. (Mean ± SD, n = 6)
| Parameter | Group | ||||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| formulation 1 | formulation 2 | formulation 3 | formulation 4 | formulation 5 | formulation 6 | formulation 7 | formulation 8 | formulation 9 | |
| T1/2(h) | 21.95 ± 2.36 | 13.06 ± 1.27 | 12.26 ± 0.29 | 11.7 ± 1.55 | 15.03 ± 2.17 | 14.41 ± 0.95 | 15.24 ± 0.74 | 4.56 ± 0.82 | 11.09 ± 1.14 |
| Tmax(h) | 0.34 ± 0.09 | 2.05 ± 0.04 | 0.32 ± 0.04 | 0.44 ± 0.06 | 0.83 ± 0.06 | 0.53 ± 0.03 | 0.55 ± 0.06 | 1.09 ± 0.07 | 0.59 ± 0.05 |
| Cmax(μg/L) | 537.21 ± 124.12 | 242.11 ± 48.23 | 131.84 ± 38.84 | 468.48 ± 44.14 | 728.72 ± 63.22 | 2413.01 ± 359.15 | 5440.03 ± 486.31 | 1427.06 ± 157.65 | 2001.02 ± 312.72 |
| AUC(0-t) (μg/L*h) | 833.29 ± 147.35 | 1313.19 ± 212.66 | 531.1 ± 96.99 | 1418.09 ± 87.94 | 1041.01 ± 102.64 | 5968.02 ± 634.58 | 5308.41 ± 589.66 | 3254.61 ± 478.31 | 5124.43 ± 229.09 |
| MRT(0-t) (h) | 2.95 ± 0.13 | 6.72 ± 0.54 | 7.14 ± 0.85 | 6.03 ± 0.95 | 2.27 ± 0.18 | 7.39 ± 0.27 | 3.04 ± 0.24 | 3.45 ± 0.67 | 6.19 ± 1.06 |