Suppl. Table 8.
The main PK parameters of formononetin in rat plasma after oral administration of different formulations. (Mean ± SD, n = 6)
| Parameter | Group | ||||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| formulation 1 | formulation 2 | formulation 3 | formulation 4 | formulation 5 | formulation 6 | formulation 7 | formulation 8 | formulation 9 | |
| T1/2(h) | 6.71 ± 1.02 | 6.18 ± 1.13 | 8.63 ± 0.64 | 5.04 ± 0.76 | 7.86 ± 0.89 | 5.18 ± 0.62 | 8.23 ± 0.92 | 18.54 ± 2.15 | 10.45 ± 1.47 |
| Tmax(h) | 0.12 ± 0.05 | 0.15 ± 0.01 | 0.25 ± 0.05 | 0.11 ± 0.04 | 0.10 ± 0.01 | 0.09 ± 0.02 | 0.11 ± 0.04 | 0.14 ± 0.07 | 0.12 ± 0.03 |
| Cmax(μg/L) | 193.32 ± 19.55 | 119.78 ± 21.22 | 117.12 ± 18.46 | 272.31 ± 32.12 | 344.56 ± 46.78 | 228.91 ± 56.11 | 725.69 ± 121.66 | 717.71 ± 98.44 | 667 ± 102.77 |
| AUC(0-t) (μg/L*h) | 249.04 ± 63.36 | 236.47 ± 74.26 | 287.07 ± 52.25 | 302.67 ± 69.65 | 295.35 ± 71.47 | 229.51 ± 74.17 | 289.28 ± 23.23 | 528.05 ± 98.31 | 763.16 ± 88.68 |
| MRT(0-t) (h) | 3.17 ± 0.57 | 8.52 ± 0.98 | 4.9 ± 0.15 | 2.85 ± 0.35 | 2.21 ± 0.54 | 6.03 ± 0.75 | 2.01 ± 0.14 | 3.71 ± 0.21 | 6.04 ± 1.08 |