Suppl. Table 9.

The main PK parameters of ononin in rat plasma after oral administration of different formulations. (Mean ± SD, n = 6)

Parameter	Group
	formulation 1	formulation 2	formulation 3	formulation 4	formulation 5	formulation 6	formulation 7	formulation 8	formulation 9
T1/2(h)	6.16 ± 0.84	15.14 ± 1.05	17.02 ± 1.07	12.72 ± 0.68	12.67 ± 0.77	15.82 ± 1.28	17.34 ± 1.04	14.45 ± 1.13	10.24 ± 0.28
Tmax(h)	0.86 ± 0.08	0.75 ± 0.04	0.58 ± 0.05	0.51 ± 0.06	0.77 ± 0.07	0.55 ± 0.05	0.71 ± 0.05	1.04 ± 0.07	0.61 ± 0.08
Cmax(μg/L)	164.61 ± 35.54	178.82 ± 32.51	187.52 ± 25.15	439.7 ± 25.65	171.42 ± 23.12	1101.56 ± 162.13	242.98 ± 26.15	368.6 ± 36.88	508.84 ± 46.56
AUC(0-t) (μg/L*h)	319.65 ± 45.64	1133.75 ± 96.64	367.27 ± 42.16	3009.78 ± 221.06	736.27 ± 54.45	1156.21 ± 166.64	550.05 ± 34.16	897.42 ± 68.91	1865.38 ± 264.16
MRT(0-t) (h)	4.28 ± 0.45	8.72 ± 0.68	6.84 ± 0.66	9.54 ± 0.72	7.89 ± 1.07	3.94 ± 0.21	6.36 ± 0.74	5.03 ± 0.46	8.02 ± 0.87