Table 3. Drug potencies and efficacies on glucose-stimulated insulin secretion (GSIS).
Potency data are represented by pIC50 with corresponding IC50 values in parentheses (in μM). Emax values represent % maximal efficacy relative to (−)-quinpirole treatment.
| Compound | pIC50 (IC50, μM) | E max |
|---|---|---|
| (−)-Quinpirole | 5.93 (1.18) | 100.00% |
| AB01–59 | 5.16 (6.94) | 51.56% |
| Bromocriptine | 6.75 (0.18) | 166.94% |
| AB01–60 | 4.99 (10.17) | 190.02% |
| Sumanirole | 3.75 (17.92) | 171.44% |
| MPE01–05 | 3.73 (18.50) | 171.44% |
| (+)-PD128,907 | 4.34 (45.43) | 195.52% |
| AB01–117 | 4.01 (98.19) | 166.63% |