Table 4. Quantification of in vivo pharmacokinetics of BrMeI versus bromocriptine in mice.
Data are represented as the mean ± SEM (n=3 per group).
Drug | Time (min) | Plasma Conc. (nmol/L) | Brain Conc. (pmol/g) | Brain/Plasma Ratio |
---|---|---|---|---|
Bromocriptine | 15 min | 1336.7 ± 52.2 | 995.2 ± 188.0 | 0.74 ± 0.11 |
60 min | 158.6 ± 15.0 | 71.1 ± 2.3 | 0.45 ± 0.05 | |
BrMel | 15 min | 4259.1 ± 381.3 | 1282.3 ± 130.7 | 0.30 ± 0.03 |
60 min | 1277.1 ± 71.1 | 651.9 ± 133.7 | 0.51 ± 0.06 |