Table 3.
Diarrhea-Associated Quantification Cycle Cutoffs Derived From the Global Enteric Multicenter Study and Malnutrition and the Consequences for Child Health and Development Study
| Pathogen | Quantification Cycle Cutoff | |||
|---|---|---|---|---|
| Whole Stool | Rectal Swab | |||
| GEMS | MAL-ED | EFGHa | EFGHb | |
| Adenovirus 40/41 | 24.7 | 22.3 | 23.5 | 25.5 |
| Aeromonas | 21.2 | 22 | 21.6 | 23.6 |
| Astrovirus | 23.8 | 24.9 | 24.4 | 26.7 |
| Campylobacter jejuni/coli | None | 19.9 | 19.9 | 20.7 |
| Cryptosporidium | 26.9 | 23.7 | 25.3 | 27.1 |
| Cyclospora cayetanensis | 31.9 | None | 31.9 | 33.9 |
| Entamoeba histolytica | 31.3 | 29.8 | 30.6 | 32.6 |
| Cystoisospora belli | None | 32.4 | 32.4 | 34.4 |
| Norovirus GII | 20.6 | 27.7 | 24.2 | 26.6 |
| Rotavirus | 32.3 | 31.3 | 31.8 | 34.2 |
| Salmonella | 31.3 | None | 31.3 | 33.3 |
| Sapovirus | 17.1 | 26.8 | 21.9 | 24.4 |
| Shigella/EIEC | 29.4 | 30.1 | 29.8 | 31.1 |
| ST-ETEC | 23 | 25.2 | 24.2 | 27.9 |
| Typical EPEC | None | 17.4 | 17.4 | 20.7 |
| Vibrio cholerae | 33.4 | 30.3 | 31.9 | 33.9 |
Abbreviations: EFGH, Enterics for Global Health; EIEC, enteroinvasive Escherichia coli; EPEC, enteropathogenic Escherichia coli; GEMS, Global Enteric Multicenter Study; MAL-ED, Malnutrition and the Consequences for Child Health and Development; ST-ETEC, enterotoxigenic Escherichia coli producing heat-stable enterotoxins.
aCalculated as the mean of GEMS and MAL-ED whole stool quantification cycle value cutoffs.
bCalculated as the mean of GEMS and MAL-ED Cq cutoffs plus the rectal swab conversion. Note that the Bangladesh and The Gambia sites will be providing additional swab-stool comparative data that could slightly alter the swab adjustment.