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. Author manuscript; available in PMC: 2024 Mar 25.
Published in final edited form as: Mol Cell. 2020 Sep 18;80(2):246–262.e4. doi: 10.1016/j.molcel.2020.09.003

Figure 8: Summary Diagrams.

Figure 8:

A) Diagram illustrating the generic action of the e-CHACRs against the MCR-GFP gene-drive. B) Diagram outlining the structures and homologous sequences serving as sites for potential SDSA-mediated partial copying between ERACR-2 and the MCR-GFP constructs (lightly shaded parallelograms). y1*, y2* and y3* indicate the loss of the gRNA-y1, gRNA-y2 and gRNA-y3 cut sites accompanying genomic insertion of the MCR-GFP element (gRNA-y1) or ERACRs (gRNA-y2 and gRNA-y3). C) Pie charts summarizing key e-CHACR performance parameters. D) Pie chart summary of F2 male and female progeny outcomes derived from F1 ERACR-2/MCR-GFP master females separated by inferred donor (w = red shaded sectors) versus receiver (wa: peach = ERACR copied, green = MCR-GFP retention; gray =MCR-GFP deleted) chromosomes.