Table 4.

ORs of SSADR according to patient, procedure, and physician characteristics by all years, 2010 and 2020

Characteristics	All yearsa	2010b	2020c	P-interactiond
	OR (95% CI)	OR (95% CI)	OR (95% CI)
Patient-related
Age
<50 yr	Reference	Reference	Reference	0.30
50–75 yr	0.82 (0.77–0.88)	1.69 (0.58–4.93)	0.75 (0.64–0.86)
>75 yr	0.80 (0.73–0.88)	1.84 (0.22–15.40)	0.54 (0.44–0.66)
Sex
Male	Reference	Reference	Reference	0.41
Female	1.21 (1.17–1.26)	0.99 (0.68–1.44)	1.16 (1.04–1.29)
BMI
<25 kg/m2	Reference	Reference	Reference	0.98
25–30 kg/m2	1.04 (0.98–1.10)	0.99 (0.42–2.35)	0.92 (0.80–1.05)
>30 kg/m2	0.99 (0.91–1.08)	0.97 (0.43–2.19)	0.93 (0.77–1.11)
Unknown	1.49 (1.33–1.66)	2.41 (1.39–4.17)	0.93 (0.78–1.11)
Race
White	Reference	Reference	Reference	0.88
Asian	0.59 (0.54–0.65)	0.63 (0.39–1.00)	0.57 (0.48–0.68)
African American	0.43 (0.36–0.51)	0.41 (0.06–3.06)	0.38 (0.22–0.65)
Other	0.57 (0.49–0.66)	0.42 (0.09–1.90)	0.62 (0.52–0.75)
Unknown	0.74 (0.67–0.81)	0.47 (0.15–1.46)	0.74 (0.59–0.92)
Smoking status
Never smoker	Reference	Reference	Reference	0.40
Current smoker	1.06 (0.97–1.15)	0.58 (0.11–3.10)	1.19 (0.92–1.54)
Former smoker	0.95 (0.89–1.00)	1.02 (0.52–2.01)	0.92 (0.80–1.05)
Unknown	0.94 (0.87–1.01)	0.40 (0.27–0.58)	1.10 (0.95–1.28)
Charlson comorbidity
0	Reference	Reference	Reference	0.13
1	0.92 (0.88–0.95)	1.34 (0.74–2.40)	0.76 (0.67–0.87)
≥2	0.85 (0.82–0.88)	1.26 (0.70–2.26)	0.80 (0.70–0.91)
Colonoscopy indication
Average risk	Reference	Reference	Reference	0.18
High risk	0.90 (0.85–0.96)	1.63 (0.75–3.51)	0.96 (0.88–1.05)
Procedure-related
Mucosal assist device
No	Reference	Reference	Reference	NAe
Yes	1.11 (0.95–1.29)	NAe	1.07 (0.88–1.29)
High-definition colonoscope
No	Reference	Reference	Reference	NAf
Yes	1.33 (1.17–1.50)	NAf	1.13 (0.79–1.61)
Unknown	2.01 (1.68–2.41)	0.87 (0.23–3.21)	1.00 (0.58–1.73)
Withdrawal time
<6 min	Reference	Reference	Reference	0.55
6–9 min	1.38 (0.83–2.32)	0.31 (0.05–1.83)	1.57 (0.54–4.53)
>9 min	4.56 (2.57–8.12)	1.11 (0.48–2.54)	4.43 (1.26–15.59)
Missing	3.80 (2.11–6.85)	NA	2.45 (0.66–9.13)
Preparation quality
Adequate (excellent, good, or fair)	Reference	Reference	Reference	0.03
Inadequate (poor)	0.79 (0.53–1.18)	3.16 (0.92–10.80)	0.40 (0.14–1.19)
Sedation type
Moderate sedation	Reference	Reference	Reference	0.75
Other	0.90 (0.82–0.99)	0.83 (0.37–1.84)	0.95 (0.81–1.12)
Physician-related
Endoscopist sex
Male physician	Reference	Reference	Reference	0.01
Female physician	1.11 (0.89–1.39)	2.54 (1.21–5.33)	0.86 (0.64–1.16)
Years in practice
<11 yr	Reference	Reference	Reference	0.002
11–25 yr	0.89 (0.71–1.13)	4.36 (1.37–13.89)	0.99 (0.77–1.27)
>25 yr	0.57 (0.30–1.08)	1.34 (0.31–5.86)	0.99 (0.82–1.20)

BMI, body mass index; CI, confidence interval; OR, odds ratio; SSADR, sessile serrated adenoma detection rate.

^aMultivariate model included variables for all patient-related, procedure-related, and physician-related characteristics and fixed effects of each year from 2010 to 2020.

^bMultivariate model in variables for all patient-related, procedure-related, and physician-related characteristics, except for mucosal assist device and high-definition colonoscope.

^cMultivariate model in variables for all patient-related, procedure-related, and physician-related characteristics.

^dP-interaction was calculated using cross product of year and with respective risk factor. Missing and unknown categories were omitted in the model to improve interpretability.

^eNo mucosal assist device was used in 2010, so interaction was not calculated.

^fInteraction term was not calculated because OR did not converge for high-definition colonoscope in 2010.