Table 1.

Baseline characteristics and clinical presentation

Patient no.	Age and sex	Sevelamer dose (mg/d)	Days on medication	Presentation	Endoscopic or surgical findings	Comorbid conditions	Follow-up
1	55 M	4,800	36	Diarrhea, nausea/vomiting	Ulcerated stenosis of sigmoid colon	Opioid-dependent chronic pain, constipation, HTN	Persistent stricture on colonoscopy, bleeding resolved
2	69 F	9,600	1,183	Diarrhea, melena	Gastric ulcer, duodenitis, ulcerated proctitis	HTN, secondary hyperparathyroidism, hypothyroidism, diabetes	No further bleeding on long-term PPI
3	52 F	12,000	1,344	Melena, hematochezia	Gastritis, gastric ulcer, normal colonic mucosa biopsied showing sevelamer crystals	CHF, orthotopic heart transplant with graft failure, chronic constipation	Repeat EGD with nonbleeding ulcer
4	32 F	2,400	60	Abdominal pain, diarrhea, jejunitis on CT	Severe jejunitis with confluent ulcerations	HIV (CD4 = 292), secondary hyperparathyroidism, HTN, chronic constipation	No further bleeding
5	27 M	4,800	117	Abdominal pain, hematochezia, fever	Ulcerated sigmoid colitis and proctitis	HIV (CD4 = 346), HTN, diabetes	No further bleeding
6	54 F	1,600	471	Abdominal pain, diarrhea, perforated appendix	Perforated appendix, surgically excised	Hepatic cirrhosis, CHF, HTN, diabetes	No surgical complications or related follow-up
7	55 F	2,400	371	Melena	Esophagitis, gastric ulcer	Dementia, HCV	H. pylori stain negative, no further follow-up
8	74 F	12,000	1,244	Abdominal pain, melena	Gastritis, gastric ulcer	HTN, PAF, calciphylaxis, opioid-dependent chronic pain, constipation	Colonoscopy next day within normal limits
9	63 M	2,400	3,249	Abdominal pain, diarrhea, diverticulitis on CT	Sigmoid perforation, surgically excised	Gout, HTN, renal transplant, prediabetes	No further bleed, on alternative phosphorus binder
10	42 F	2,400	980	Nausea/vomiting, diarrhea	Diffuse pseudomembranous enterocolitis	Crohn disease, HPV, hypertrophic cardiomyopathy, diabetes	No further bleeding on PPI, C. difficile antigen and toxin negative
11	78 F	2,400	29	Anemia	Transmural cecal necrosis, surgically excised	HTN, diverticulosis, DVT, gout	Passed away shortly after surgery
12	81 M	2,400	2,198	Abdominal pain	Exploratory laparoscopy with dilated bowel, partially excised	Chronic hypotension, multiple myeloma	No further bleeding

CHF, congestive heart failure; DVT, deep vein thrombosis; HCV, hepatitis C virus; HPV, human papilloma virus; HTN, hypertension; PAF, paroxysmal atrial fibrillation; PPI, proton pump inhibitor.