Table 2.

Univariate and multivariate analyses of NRIP3 methylation status with 5-year overall survival in patients with CRC

Clinical parameter	Univariate analysis		Multivariate analysis
	HR (95% CI)	P value	HR (95% CI)	P value
Gender (male vs female)	1.345 (0.692–2.615)	0.382
Age (≥50 vs <50 yr)	1.418 (0.730–2.757)	0.303
Tumor size (≥4 vs <4 cm)	1.211 (0.635–2.307)	0.561
Differentiation (low vs high or middle differentiation)	2.420 (1.231–4.757)	0.010a	1.476 (0.730–2.984)	0.278
TNM stage (III/IV vs I/II)	4.831 (2.384–9.791)	0.000b	11.185 (3.008–41.587)	0.000b
Lymph node metastasis (positive vs negative)	3.358 (1.727–6.530)	0.000b	0.341 (0.097–1.195)	0.093
NRIP3 (methylation vs unmethylation)	2.396 (1.203–4.773)	0.013a	2.256 (1.069–4.761)	0.033a
Tumor location (distal vs proximal)	0.648 (0.330–1.272)	0.208

CI, confidence interval; HR, hazard ratio.

^aP < 0.05.

^bP < 0.001.