Table 2.

Frequency of Cognitive Impairment in TARDBP and WT-ALS Patients

	TARDBP (N = 33)	WT-ALS (N = 928)
ALS-CN, n (%)	18 (54.5)	546 (58.8)
Cognitively impaired ALS, n (%)	15 (45.5)	382 (41.1)
ALSci, n (%)	7 (21.2)	170 (18.3)
ALSbi, n (%)	3 (9.1)	88 (9.5)
ALScbi, n (%)	2 (6.1)	62 (6.7)
ALS-FTD, n (%)	3 (9.1)	62 (6.7)

Abbreviations: ALS = amyotrophic lateral sclerosis; ALSbi = patients with isolated behavioral impairment; ALScbi = patients with both cognitive and behavioral impairment; ALSci = patients with isolated cognitive impairment; ALS-CN = patients with normal cognition; ALS FTD = patients with frontotemporal dementia; WT-ALS = ALS patients not carrying pathogenic variants.

ALS-CN vs cognitively impaired ALS, p = 0.623.