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. 2024 Mar 14;121(12):e2307250121. doi: 10.1073/pnas.2307250121

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Copyright © 2024 the Author(s). Published by PNAS.

This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 6. — Loss of SRF induces oligodendrocyte disease–associated genes. (A) UMAP plot showing Seurat clusters and their annotation of 10-mo-old SRF-Flox and SRF-cKO NeuN⁻ nuclei sequenced by 10× snRNA-seq. (B) Bar graph showing the number of DEGs significantly (P.adj < 0.05) up- (red) or down-regulated (blue) in each Seurat cluster. (C) Pathways enriched or depleted in SRF-cKO oligodendrocytes (clusters 0 and 2 combined) detected by Gene Set Enrichment Analysis (GSEA) of descending Log 2FC. (D) Violin plots of expression levels and P-adj. values of top differentiated mature oligodendrocyte marker genes. (E) Scatter plot showing the normalized expression of C4b overlayed over the oligodendrocyte clusters (0 and 2) split by SRF-Floxed and SRF-cKO groups. (F) Scatter plot showing the normalized expression of Serpina3n overlayed over the oligodendrocyte clusters (0 and 2) split by SRF-Floxed and SRF-cKO groups. (G) Scatter plot showing the normalized expression of Piezo2 overlayed over the oligodendrocyte clusters (0 and 2) split by SRF-Floxed and SRF-cKO groups.