FIG. 4.
Effects of the LMP1 variants on the activation of NF-κB on the cell lines Eli-BL (A), Daudi (B), DG75 (C), and Jurkat (D), as determined by quantitation of the luciferase produced from a cotransfected reporter plasmid, 3Enh.κB-ConALuc, regulated by NF-κB. The data were normalized for transfection efficiency by measuring the β-galactosidase enzyme produced from a cotransfected constitutively active reporter plasmid. The data were then expressed relative to the activity obtained with the B95.8 LMP1 gene (100%) without subtracting the basal activity in control pSG5-transfected cells. The data for each cell line are the mean and standard deviation of at least four separate experiments.