Extended Data Table 5.

Association of serum trigonelline levels with muscle mRNA expression of demethylase and methyltransferase genes in the Singapore Sarcopenia Study

Serum trigonelline levels measured with LC–MS/MS in the Singapore Sarcopenia study of MEMOSA was associated with gene expression measured using RNA sequencing in muscle biopsies, analysed with a Spearman rank correlation, filtered for genes expressed in skeletal muscle and annotated with methyltransferase or demethylase activity.