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. 2024 Feb 26;6(3):578–597. doi: 10.1038/s42255-024-00988-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — (a) The taxonomic profile of the gut microbiome at the species level for all the samples from RS and CS intervention. The samples were named using the rules of “Intervention (RS or CS) individual ID_time point (week 0 or 8). (b-e) Analysis of baseline microbial composition between RS intervention baseline and CS intervention baseline. (b) Beta-diversity for the CS-Washout-RS group using the Bray–Curtis distance method. (c) Beta-diversity for the RS-Washout-CS group using the Bray–Curtis distance method. (d) Beta-diversity for the CS-Washout-RS group using the weighted-Unifrac distance method. (e) Beta-diversity for the RS-Washout-CS group using the weighted-Unifrac distance method. All the beta-diversity plots used Non-metric multidimensional scaling (NMDS) based on the compositional profile of the species abundance. The ANOSIM results support the baseline comparability of microbial compositions (P > 0.05).

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