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. 2024 Jan 17;11(3):729–743. doi: 10.1002/acn3.51996

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© 2024 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Single‐protein model parameters predicting shifts in outcome score using shifts in biomarker concentration with adjustment for age, sex, and BMI. The radius of each circle is proportional to the estimated standardized coefficient of the corresponding protein; red (blue) circles represent proteins with positive (negative) effects in estimating the second‐class label. The opacity of each circle represents the p‐value; a p‐value < 0.001 corresponds to full opacity, and a p‐value of 0.05 corresponds to the least opacity. Biomarkers that survived the multiple comparison correction are marked with a gold star (*).