Table 2.

Completed and in-progress clinical studies using MSC-based treatment for DKD

	Completed		Registered with NLM
Clinical trial ID	NCT01843387	NCT02585622	NCT02585622	NCT04216849	NCT03288571	NCT03840343	NCT04125329	NCT04562025
Phase	I	Ib/IIa	I, II	I, II	I, II	I	Early phase I	N/A
No. of subjects	30	14	48	54	20	30	15	38
Route	IV	IV	IV	IV	Renal parenchyma	Intra-arterial delivery (single kidney)	Peripheral IV injection	IV
MSCs type	BM-MPC	ORBCEL-M	BM-MSCs	UC-MSCs	UC WJ-MSC	AD-MSCs	UC-MSCs	UC-MSCs
Dose and frequency	1 dose: 150, 300 × 106 cells	80 × 106 cells	1 dose: 80, 160, 240 × 106 cells	5 doses: 1.5 × 106 cells/kg	3 doses: 3 ml/kidney	2 doses: 2.5, 5 × 105 cells/kg	3 doses: 1 × 106 cells/kg	3 doses: 1 × 106 cells
Trial status	COMPLETED	COMPLETED	Recruiting	Unknown	Unknown	Recruiting	Recruiting	N/A

NLM National Library of Medicine, MSC mesenchymal stem cells, BM-MPC bone marrow mesenchymal precursor cells, UC umbilical cord, WJ Wharton jelly, AD-MSC adipose-derived MSC