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. 2024 Mar 25;150(3):155. doi: 10.1007/s00432-024-05658-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — OPN regulates GPX4-mediated anti-lipid peroxidation by activating PI3K/AKT/mTOR signaling pathway to affect tumor sphere formation and vascular formation in TNBC. A The levels of MDA and GSD were detected with corresponding kits. B Western blot detected the expressions of OPN and PI3K/AKT/mTOR signaling pathway-related proteins. C Western blot detected the expressions of autophagy-related proteins in the downstream of mTOR signaling. *p < 0.05, **p < 0.01, ***p < 0.001 vs vector; ^#p < 0.05, ^###p < 0.001 vs OPN-OE