Fig. 7.

OPN regulates GPX4-mediated anti-lipid peroxidation by activating PI3K/AKT/mTOR signaling pathway to affect cell tumor sphere formation and vascular formation in TNBC in vivo. A The mice were photographed. B The weight of the mice. C The tumor of mice was photographed. D The tumor volume was observed. E The tumor weight was observed. F, G IHC detected the expression of VWF. H The levels of MDA and GSD were detected with corresponding kits. I Western blot detected the expressions of OPN and PI3K/AKT/mTOR signaling pathway-related proteins. n = 5. *p < 0.05, **p < 0.01, ***p < 0.001 vs vector; ^#p < 0.05, ^###p < 0.001 vs OPN-OE