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. 2024 Mar 12;15:1334762. doi: 10.3389/fimmu.2024.1334762

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Copyright © 2024 Salerno-Goncalves, Chen, Bafford, Izquierdo, Hormazábal, Lagos, Tettelin, D’Mello, Booth, Fasano, Levine and Sztein

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Establishment of the HODGM model. (A) Cartoon of the model. (B) Feeder layer of fibroblasts. (C) Co-culture of stem cells and feeder cells in a laminin-rich matrix (Matrigel) and the formation of 2-D colonies (red arrows). Cells from a differentiated model, H&E, at (D) lower and (E) higher magnification. Immunochemical staining of the HODGM model to detect the presence of (F) microvilli using an anti-villin mAb, (G) tight junctions using an anti-claudin 3 mAb, and (H) mucus using Alcian Blue at higher magnification.