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. 2024 Mar 13;10(6):e28143. doi: 10.1016/j.heliyon.2024.e28143

Table 1.

The baseline characteristics of the total population.

Variables deletion Classification items All (n = 279) Non-ARDS
(n = 112)		 ARDS
(n = 167)		 statistic P - value
Blood transfusion therapy (Yes = 1 No = 0), n (%) 0 0 1 (0.358) 1 (0.893) 0 (0.000) nan nan
1 278 (99.642) 111 (99.107) 167 (100.000)
Gender male 1, female 0, n (%) 0 0 80 (28.674) 43 (38.393) 37 (22.156) 8.642 0.003
1 199 (71.326) 69 (61.607) 130 (77.844)
FIB g/L, median [IQR] 0 nan 3.320 [1.990,4.830] 2.990 [1.830,4.470] 3.530 [2.050,4.830] −1.341 0.180
APTT s, median [IQR] 0 nan 43.100 [33.500,57.400] 43.600 [32.800,55.900] 42.700 [34.800,58.000] −0.511 0.610
INR, median [IQR] 0 nan 1.290 [1.140,1.580] 1.230 [1.100,1.510] 1.310 [1.160,1.620] −1.387 0.166
PT s, median [IQR] 0 nan 14.900 [13.200,18.100] 14.200 [12.800,16.900] 15.000 [13.300,18.500] −1.485 0.138
PTA %, mean (±SD) 0 nan 62.489 ± 25.394 66.740 ± 26.214 59.638 ± 24.417 2.303 0.022
D-dimer mg/L, median [IQR] 0 nan 4.640 [2.210,10.290] 4.797 [2.310,11.310] 4.480 [2.100,10.250] 0.702 0.483
pH, median [IQR] 0 nan 7.400 [7.330,7.454] 7.401 [7.350,7.455] 7.390 [7.310,7.450] 1.401 0.161
Mechanical Ventilation (No = 0 < 96 h = 1 ≥ 96 h = 2), median [IQR] 0 nan 2.000 [1.000,2.000] 2.000 [1.000,2.000] 2.000 [1.000,2.000] −0.354 0.664
Age, median [IQR] 0 nan 61.000 [48.000,69.000] 62.000 [48.000,72.000] 61.000 [48.000,68.000] 0.590 0.555
Cl mmol/L, median [IQR] 0 nan 113.000 [108.000,117.739] 113.000 [107.000,117.000] 113.000 [108.487,118.000] −0.759 0.448
SO2c %, median [IQR] 0 nan 96.757 [93.747,98.485] 97.686 [95.900,99.000] 95.800 [91.300,97.834] 4.983 <0.001
Hb (BGA) g/L, median [IQR] 0 nan 99.00 [83.05,116.08] 98.00 [82.83,115.83] 101.00 [85.18,119.00] −1.001 0.317
PO2 mmHg, median [IQR] 0 nan 85.900 [72.900,117.000] 102.509 [83.653,133.000] 76.700 [65.400,98.100] 5.577 <0.001
PCO2 mmHg, median [IQR] 0 nan 31.900 [27.300,38.700] 31.922 [27.200,37.111] 31.900 [27.387,39.200] −0.524 0.601
oxygen content vol%, median [IQR] 0 nan 14.900 [11.700,18.468] 16.200 [12.200,18.468] 14.200 [11.400,17.400] 2.725 0.006
PO2(T) mmHg, median [IQR] 0 nan 100.000 [71.000,113.000] 111.237 [95.600,134.000] 80.300 [65.400,111.237] 6.381 <0.001
PCO2(T)mmHg, median [IQR] 0 nan 34.846 [28.100,37.300] 34.846 [29.600,35.400] 34.846 [27.500,38.700] 0.028 0.978
pH(T), median [IQR] 0 nan 7.356 [7.330,7.420] 7.356 [7.350,7.410] 7.356 [7.320,7.421] −0.058 0.955
Lac mmol/L, median [IQR] 0 nan 3.800 [1.700,5.298] 4.400 [1.400,5.298] 3.800 [2.100,5.298] −0.480 0.630
SB mmol/L, median [IQR] 0 nan 17.610 [16.400,20.800] 17.610 [17.500,20.600] 17.610 [16.100,21.100] 0.112 0.911
AB mmol/L, median [IQR] 0 nan 19.152 [17.600,21.600] 19.152 [19.152,21.400] 19.152 [17.100,21.600] 0.911 0.360
A-BE mmol/L, median [IQR] 0 nan −6.498 [-8.200,-3.100] −6.498 [-6.498,-3.200] −6.498 [-8.400,-3.000] 0.481 0.629
S-BE mmol/L, median [IQR] 0 nan −6.821 [-8.400,-3.200] −6.821 [-6.821,-3.500] −6.821 [-8.700,-3.200] 0.671 0.500
P50 mmHg, median [IQR] 0 nan 27.452 [25.230,28.220] 27.452 [25.430,27.770] 27.400 [24.850,29.150] 0.480 0.630
AG mmol/L, median [IQR] 0 nan 8.300 [0.925,13.300] 5.600 [0.925,13.000] 9.000 [0.925,13.300] −1.202 0.227
RI %, median [IQR] 0 nan 129.000 [110.988,299.000] 110.988 [66.000,129.000] 201.000 [110.988,380.000] −6.741 <0.001
PaO2/PAO2 mmHg, median [IQR] 0 nan 44.200 [25.100,57.047] 57.047 [43.700,60.200] 34.600 [20.800,53.000] 6.764 <0.001
A-aDO2 mmHg, median [IQR] 0 nan 146.758 [124.800,225.400] 146.758 [98.600,147.600] 163.100 [139.300,299.500] −4.920 <0.001
TCO2 vol%, median [IQR] 0 nan 38.732 [34.400,42.800] 38.732 [36.900,41.900] 38.732 [33.800,43.100] 0.427 0.669
K mmol/L, median [IQR] 0 nan 3.700 [3.252,4.300] 3.500 [3.252,4.100] 3.800 [3.252,4.300] −2.288 0.021
Ca mmol/L, median [IQR] 0 nan 1.020 [1.010,1.120] 1.020 [1.020,1.110] 1.030 [0.990,1.120] 0.076 0.940
Hct (BGA) %, median [IQR] 0 nan 34.800 [27.900,37.007] 36.500 [27.900,37.007] 34.200 [28.000,37.007] 0.452 0.650
FiO2, median [IQR] 0 nan 42.256 [35.000,50.000] 42.256 [34.000,42.256] 42.256 [37.000,60.000] −2.408 0.015
TEMP °C, median [IQR] 0 nan 37.000 [36.800,37.373] 37.373 [37.000,37.373] 37.000 [36.600,37.373] 2.352 0.017
Platelets 109/L, median [IQR] 0 nan 107.000 [47.000,191.000] 107.000 [45.000,179.000] 107.000 [49.000,201.000] −0.429 0.668
Hct %, median [IQR] 0 nan 31.200 [25.100,37.100] 30.000 [23.800,37.300] 31.400 [26.200,36.700] −0.832 0.406
Hemoglobin g/L, median [IQR] 0 nan 98.000 [77.000,118.000] 93.000 [69.000,116.000] 102.000 [82.000,120.000] −2.317 0.021
WBC 109/L, median [IQR] 0 nan 11.320 [6.350,17.880] 11.840 [7.820,19.790] 10.890 [6.050,16.660] 1.586 0.113
Na mmol/L, median [IQR] 0 nan 138.000 [134.000,142.000] 138.000 [134.000,141.077] 138.000 [134.000,142.000] −0.786 0.432
MCHC g/L, median [IQR] 0 nan 326.000 [316.000,337.000] 326.000 [312.000,337.000] 326.000 [318.000,335.000] −0.351 0.726
MCH pg, median [IQR] 0 nan 30.700 [29.300,31.800] 30.900 [29.300,33.000] 30.500 [29.400,31.600] 1.944 0.052
MCV fL, median [IQR] 0 nan 93.800 [88.200,98.000] 94.364 [88.300,100.500] 92.700 [88.100,96.400] 2.030 0.042
RBC 1012/L, median [IQR] 0 nan 3.360 [2.780,4.040] 3.210 [2.710,3.970] 3.450 [2.890,4.040] −1.158 0.247
Monocyte count 109/L, median [IQR] 0 nan 0.450 [0.200,0.810] 0.490 [0.260,0.870] 0.410 [0.190,0.710] 1.896 0.058
Basophils %, median [IQR] 0 nan 0.100 [0.100,0.300] 0.200 [0.100,0.400] 0.100 [0.100,0.300] 0.675 0.492
Eosinophils %, median [IQR] 0 nan 0.100 [0.000,0.504] 0.200 [0.000,0.500] 0.100 [0.000,0.504] 1.010 0.299
Monocyte %, median [IQR] 0 nan 3.800 [2.000,6.600] 4.000 [1.700,6.200] 3.800 [2.300,6.800] −0.899 0.369
Lymphocyte %, median [IQR] 0 nan 8.900 [4.300,16.000] 10.672 [4.700,17.500] 7.800 [4.200,15.200] 1.810 0.070
Neutrophils %, median [IQR] 0 nan 85.100 [76.000,91.500] 84.400 [73.900,90.700] 86.100 [76.900,91.700] −1.663 0.096
RDW %, median [IQR] 0 nan 14.100 [13.100,15.700] 14.400 [13.100,16.100] 14.000 [13.100,15.300] 1.361 0.174
Basophils count 109/L, median [IQR] 0 nan 0.010 [0.000,0.030] 0.020 [0.010,0.030] 0.010 [0.000,0.030] 0.997 0.310
Eosinophils count 109/L, median [IQR] 0 nan 0.010 [0.000,0.060] 0.010 [0.000,0.060] 0.010 [0.000,0.060] 1.539 0.111
Neutrophils count 109/L, median [IQR] 0 nan 9.100 [5.420,14.690] 9.910 [6.110,16.650] 8.845 [5.170,14.380] 1.325 0.185
Lymphocyte count 109/L, median [IQR] 0 nan 0.690 [0.400,1.220] 0.880 [0.490,1.270] 0.650 [0.370,1.090] 2.713 0.007
CRP mg/L, median [IQR] 0 nan 127.115 [71.465,200.000] 105.782 [61.869,167.803] 145.480 [88.490,216.990] −3.530 <0.001
platelet hyperplasia %, median [IQR] 0 nan 0.137 [0.080,0.220] 0.140 [0.090,0.220] 0.130 [0.070,0.220] 1.367 0.172
MPV fL, mean (±SD) 0 nan 10.693 ± 1.417 10.715 ± 1.230 10.678 ± 1.530 0.219 0.827
PDW fL, median [IQR] 0 nan 16.400 [15.900,16.900] 16.300 [15.900,16.811] 16.405 [15.900,16.900] −0.813 0.416
RDW (fL),median [IQR] 0 nan 48.703 [44.436,54.300] 50.900 [45.746,56.200] 47.100 [44.148,51.700] 2.641 0.008
TP g/L, median [IQR] 0 nan 50.500 [44.500,57.400] 51.500 [45.100,58.800] 50.000 [44.300,56.600] 1.072 0.284
DBil μmol/L, median [IQR] 0 nan 8.100 [4.500,19.200] 7.000 [3.500,18.400] 9.000 [5.200,19.500] −1.651 0.099
TBil μmol/L, median [IQR] 0 nan 15.900 [10.000,31.700] 13.700 [9.000,28.900] 17.200 [10.700,33.800] −1.636 0.102
AST, median [IQR] 0 nan 62.000 [27.000,201.000] 58.000 [29.000,180.000] 66.000 [27.000,214.000] −1.281 0.201
ALT, median [IQR] 0 nan 36.000 [16.000,111.000] 29.000 [14.000,109.000] 39.000 [18.000,111.000] −1.133 0.257
Urea mmol/L, median [IQR] 0 nan 12.193 [7.410,18.670] 11.660 [6.120,18.340] 12.610 [8.260,18.800] −1.186 0.236
TBA μmol/L, median [IQR] 0 nan 6.100 [3.000,16.800] 5.900 [3.000,24.100] 6.200 [3.100,14.900] 0.298 0.766
A/G, median [IQR] 0 nan 1.300 [1.000,1.500] 1.200 [0.900,1.500] 1.300 [1.000,1.600] −1.307 0.190
Globulin g/L, median [IQR] 0 nan 22.400 [18.200,27.200] 23.500 [18.800,28.700] 21.900 [18.000,25.825] 1.610 0.108
Albumin g/L, mean (±SD) 0 nan 27.810 ± 6.598 28.285 ± 6.898 27.491 ± 6.368 0.983 0.326
CK-MB, median [IQR] 0 nan 35.000 [21.000,72.000] 34.000 [18.154,58.000] 37.000 [22.000,85.000] −1.682 0.093
LDH, median [IQR] 0 nan 451.000 [287.000,863.000] 363.446 [279.000,781.000] 500.000 [305.000,953.000] −2.132 0.033
CK, median [IQR] 0 nan 379.000 [108.000,1425.000] 242.000 [86.000,837.000] 521.000 [146.000,1730.000] −2.633 0.008
UA μmol/L, median [IQR] 0 nan 347.000 [236.000,474.000] 363.000 [245.000,472.000] 346.000 [236.000,493.000] 0.682 0.496
Cre μmol/L, median [IQR] 0 nan 135.000 [81.000,263.000] 131.000 [80.000,264.000] 140.000 [82.000,253.000] −0.291 0.771
Mb ng/ml, median [IQR] 0 nan 564.000 [177.700,1199.000] 370.800 [151.300,997.174] 749.600 [263.600,1221.400] −2.421 0.016
PCT ng/ml, median [IQR] 0 nan 7.579 [2.070,35.980] 4.980 [1.230,32.910] 10.350 [2.560,38.980] −1.927 0.054
TT s, median [IQR] 0 nan 18.000 [16.300,21.100] 18.200 [16.600,21.600] 17.900 [16.100,20.800] 1.381 0.168
Glu, median [IQR] 0 nan 0.000 [0.000,0.000] 0.000 [0.000,0.000] 0.000 [0.000,0.000] −0.015 0.983
SG, median [IQR] 0 nan 1.018 [1.015,1.020] 1.018 [1.015,1.020] 1.020 [1.015,1.020] −2.318 0.018
Pro, median [IQR] 0 nan 1.000 [0.000,1.000] 1.000 [0.000,1.000] 1.000 [0.000,1.000] −2.040 0.016

APTT: activated partial thromboplastin time; TT: thrombin time; INR: international normalized ratio; PTA: prothrombin time activity; SO2c: oxygen saturation; Lac: lactic acid; SB: standard bicarbonate; AB: actual bicarbonate; S-BE: standard base excess; A-BE: actual base excess; AG: anion gap; RI: respiratory index; TBA: total bile acid; A/G: Albumin/Globulin; BGA: Blood Gas Analysis. nan, Not A number.