Fig. 4. Bubble plot of the potentially causal relationship between selected traits and risk of different cancers.

The columns correspond to different cancer types. The colours on the heatmap correspond to the strength of associations (odds ratio) and their direction (red positively correlated, blue negatively correlated). P-values represent the results from two-sided tests and are unadjusted. The size of each node corresponds to the -log₁₀ P-value, with increasing size indicating a smaller P-value. In the available R/Shiny app (https://software.icr.ac.uk/app/mrcan), moving the cursor on top of each bubble will reveal the underlying MR statistics.