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. 2024 Mar 25;14:7082. doi: 10.1038/s41598-024-57854-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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FOXA1 and H3K27ac ChIP-Seq in FOXA1 wild-type versus altered cells at the SEMA3C locus. To identify differential recruitment of FOXA1 (a) and H3K27ac (b) to SEMA3C imposed by FOXA1 alterations, bigWig (upper) and narrowPeak (lower) ChIP-Seq files produced by Gao et al., were examined in Integrative Genomics Viewer. FOXA1 and H3K27ac ChIP-Seqs in wildtype (blue), FOXA1 p.D226G (orange), and FOXA1 p.M253K (green) are displayed as indicated. The SEMA3C gene is shown below. Y-axes are fixed at 6.0 for the FOXA1 bigWig files and 1.5 for the H3K27ac bigWig files. Regions with a particularly dramatic shift in chromatin constituents between WT and variants are highlighted by red arrows and boxed.