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. 2024 Mar 25;14:7082. doi: 10.1038/s41598-024-57854-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Global expression in murine organoids overexpressing Foxa1 constructs. Volcano plots comparing p.F254_E255del to WT (a) and p.R219S to WT (b) in the RNA-Seq data by Adams et al. (subseries GSE128666). X-axis is log2-fold change and y-axis is − log10 p-value. Day 1 triplicate data from Adams et al. was used. Expression is relative to wild-type Foxa1. Red is ≥ twofold upregulation and p < 0.05; blue is ≥ twofold downregulation and p < 0.05. The expression of Sema3c is indicated. Within the plot, Sema3c is highlighted. (c) ATAC-Seq bigWig files (subseries GSE128421) were visualized in Integrative Genomics Viewer. Day 0 and 1 in empty vector (black), wildtype (blue), Foxa1 p.F254_E255del (red), and Foxa1 p.R219S (cyan) are displayed. The Sema3c gene is shown below. Y-axes are fixed at 250.