Figure 4.

FOXA1 and AR DNA motifs at the human SEMA3C locus. (a) The ChIP-Seq peak data derived from the three experiments on FOXA1 in LNCaP, AR in LNCaP and FOXA1 in VCaP cells³⁴ are shown as vertical black bars overlaid on the SEMA3C locus (blue horizontal line: exons are shown as vertical blue bars) using the UCSC Genome Browser (hg18, chromosome 7). The DNA sequences containing the FOXA1 and AR motifs, as predicted by the RSAT and JASPAR programs, are shown within the peak that spans from genomic positions 80,351,826 to 80,352,350 within intron 2 of SEMA3C. DNA sequences that match the consensus motifs are colored accordingly. The AR motif is located on the positive ( +) strand, and the FOXA1 motif is located on the minus (−) strand, both shown in a rectangular box respectively. (b) A consensus FOXA1 motif as reported in the JASPAR database is shown by a sequence logo. (c) A consensus AR motif as reported in the JASPAR database is shown by a sequence logo.