Table 5. ROC analyses of main echocardiographic parameters to detect light-chain cardiac amyloidosis with non-apical sparing among patients with left ventricular wall thickening.
| Parameters | AUC | 95% CI | Cut-off | Sensitivity (%) | Specificity (%) | P value |
|---|---|---|---|---|---|---|
| E/e’ ratio | 0.57 | 0.48–0.67 | 10.9 | 65.4 | 50.0 | 0.14 |
| GLSmid (%) | 0.69 | 0.60–0.79 | −12.6 | 55.8 | 85.3 | <0.001 |
| LASr (%) | 0.77 | 0.69–0.83 | 23 | 78.8 | 69.6 | <0.001 |
| LAScd (%) | 0.68 | 0.60–0.76 | −10 | 63.5 | 67.6 | <0.001 |
| LASct (%) | 0.75 | 0.67–0.81 | −13 | 71.2 | 75.5 | <0.001 |
| RV GS (%) | 0.84 | 0.77–0.89 | −21.0 | 76.9 | 81.4 | <0.001 |
| RV FWS (%) | 0.84 | 0.77–0.89 | −26.4 | 75.0 | 81.4 | <0.001 |
ROC analyses excluded AL CA patients with apical sparing. ROC, receiver operating characteristic curve; AUC, area under the curve; 95% CI, 95% confidence interval; GLSmid, global longitudinal strain of mid layer; LASr, left atrial reservoir strain; LAScd, left atrial conduit strain; LASct, left atrial contraction strain; RV, right ventricular; GS, global strain; FWS, free wall strain; AL CA, light-chain cardiac amyloidosis.