Table 4.
Compounds prioritized for follow-up studies and their corresponding physicochemical properties and stability in liver microsomes.
| GARDP0015589 | GARDP0016418 | |
|---|---|---|
| Structure |  |
 |
| A. baumannii NCTC 13424 EC50/MIC (μM) | 11.7/25 | 10.8/12.5 |
| Molecular weight (Da) | 261.69 | 323.77 |
| cLogD | 1.40 | 1.12 |
| AlogP | 1.29 | 1.12 |
| Number of rotatable bonds | 4 | 1 |
| Number of ionizable amines | 1 | 1 |
| Globularity | 0.11 | 0.08 |
| Fsp3 | 0.13 | 0.53 |
| Kinetic solubility (μM) | >100 | 82 |
| Stability in human liver microsomes (% remaining after 15 min) | 71–123% | 93–139% |
| Stability in mouse liver microsomes (% remaining after 15 min) | 67–102% | 0.4% |