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. 2024 Jan 4;21(2):e00312. doi: 10.1016/j.neurot.2023.e00312

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — Administration of sRAGE reduced vasoconstriction of small arterioles on the brain surface after SAH. (A) A 3 × 3 mm cranial window was created using a motorized drill and the left skull was exposed (lower panel). After removing dura, the blood vessels on the surface of the brain was observed (upper panel). (B) The vasculature images under capillary videoscopy were captured from the (B1&2) control, (B3&4) SAH24h + Veh, (B5&6) SAH24h + sRAGE, (B7&8) SAH48h + Veh and (B9&10) SAH48h + sRAGE groups (2 animals per group). The vasculature, including the artery (a) and vein (v), was clearly seen on the brain surface. (C) Quantitation of the arteriole diameters of primary (pa), secondary (sa) and terminal (ta) arterioles from 5 groups. Data are expressed as means ± SD. Scale bar = 100 μm ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001 (n = 5 in each group).