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Effects of sRAGE on endothelial dysfunction at 24 h and 48 h after SAH. Levels of (A) ET-1, (B) ADMA and (C) DDAH2 in rat CSF were measured by ELISA. Treatment with sRAGE significantly decreased the levels of ET-1 and ADMA, and increased DDAH2 as compared with the SAH48h + Veh group. Data are expressed as means ± SD. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001 (n = 4–5 in each group, one data in analysis of ADMA levels had to be excluded due to out of the measurement range).
